How does Parkinson's disease affect the organs in the nervous system?


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    One Response to “How does Parkinson's disease affect the organs in the nervous system?”

    • Mags says:

      Below is a compilation on my Yahoo!Answers on prior occasions:

      Don’t let anyone tell you that the brain is the only organ which suffers in PD. The entire body is affected.

      Here are the organs of the body:
      Organs and Organ Systems:
      Skin
      Skeletal System composed of bones, cartilage, tendons & ligaments
      Muscular system: skeletal and smooth muscles
      Circulatory system: heart, blood vessels and blood
      Nervous System: To relay electrical signals throughout brain, spinal cord and peripheral nerves
      Respiratory system: nose, trachea, lungs
      Digestive system: Mouth, esophagus, stomach, liver, intestines
      Excretory Syseem: Kidneys, ureters, badder, urethra
      Endocrine System: pancreas, adrenal glands, etc
      Reproductive system: testes, seminal vesicles, penis, ovaries, oviducts,uterus, vagina, mammary glands
      Lymphatic/Immune System:
      Lymph, nodes & vessels, white blood cells, T- and B- cells

      Below are the symptoms of PD
      Symptoms:
      Automatic movements such as blinking, sweating – Brain
      Constipation: Brain (because of muscle rigidity and Digestive organs – same reasons)
      Difficulty starting or continuing movement: Brain but the eyes can also be involved to assist the way out of the freeze.
      Dystonia/dyskinesia – often a result of medication wearing off
      Impaired balance of walking: Brain, muscular and skeletal systems
      (see this link to an interesting research abstract: http://brain.oxfordjournals.org/cgi/cont…
      Drooling: lack of ability to swallow – stiffening of muscles
      Lack of facial expression: stiffening of muscles
      Loss of small or fine hand movements: muscles stiffen
      Muscle aches (myalgia) and joint aches from stiffening
      Problems with movement – sitting, standing, walking, getting into and out of bed
      Rigid or stiff muscles
      Shaking, tremors
      Shuffling gait: (part of muscle rigidity, lack of balance)
      Slowed movements:
      Slowed, quiet speech, monotone voice
      Slowed thought processes
      Stooped posture:
      Fainting: (orthostatic hypotension – blood pressure) medication side effects also
      Loss of muscle function or feeling:
      Variations in heart rate:
      Urinary problems: urinary frequency, urinary hesitancy, incontinence
      Sexual Dysfunction

      Non-motor:
      Anxiety, stress, tension
      Dementia
      Depression
      Hallucinations (this is also a side effect of some meds)
      Memory Loss
      Loss of sense of smell/taste
      Vision disorders
      Sleep disorders
      Seborrhea or seborrheic dermatitis:
      Loss of cognitive skills:
      Liver is stressed and overstressed because many of the medications are processed by the liver.

      Despite all of the above, PD patients have a remarkable low suicide rate. Many survive by maintaining a sense of humor, others through hope for a cure.

      More is being learned about Parkinson’s disease every week but as more is learned researchers realize how much more there is to learn including the very reasons that the disease initiates. More research is being done about the genetics, the chemistry, the triggers for Parkinson’s. Techniques are being researched, developed which will improve existing therapies. Is there a cure in pipeline? It is difficult to say. There may be more than one type of cure needed because of the many variations of the disease. Will a cure reverse the disease and restore the lost neurons or will it simple stop all further progression. One thing that is known is that prompt treatment is needed as soon as there is a diagnosis. And that better diagnostics (in the works) are needed to speed the ability to diagnose. The medical profession needs to learn as much as possible about the very early warning signs, the precursors to the disease, in order to begin treatment possibly years earlier – if not with medication than with nutritional supplements, diet and an exercise routine which makes Forced Exercise available at an affordable price.

      diagnostics available now
      http://parkinsonsfocustoday.blogspot.com/2009/03/questions-about-parkinsons-disease-part_3744.html

      The endocrine system
      http://kidshealth.org/parent/general/body_basics/endocrine.html#

      Prolactin as an index of dopaminergic receptor function in PD. 1981
      http://www.springerlink.com/content/x0t44836307273rn/

      Estrogen
      http://www.pdcaregiver.org/Estrogen.html

      Endocrine system – good table of all endocrines and their functions
      http://en.wikipedia.org/wiki/Endocrine_system#Table_of_endocrine_glands_and_secreted_hormones_discovered

      Hormones are informational molecules
      they travel through the blood to signal distant parts of the body to do
      something. Human growth hormone signals cell division and bone growth. It
      only works on cells that have the proper receptor or "docking station" on
      their surfaces.
      Enzymes are catalysts, they make chemical reactions go
      faster than they normally would so metabolism can take place at a useful rate

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